Timing still key to treating hypoxic ischaemic brain injury
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Timing still key to treating hypoxic ischaemic brain injury
Perinatal hypoxic ischaemic encephalopathy is a devastating disorder that aff ects roughly two per 1000 term infants despite modern obstetric care. The important breakthrough in clinical and experimental studies was that, in many cases, brain oxidative metabolism transiently recovers to normal for some hours even after severe hypoxia–ischaemia before then failing again. This observation suggest...
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Epidemiological studies show a markedly increased risk of cerebral palsy following the combined exposure of infection and birth asphyxia. However, the underlying mechanisms of this increased vulnerability remain unclear. We have examined the effects of a low dose of bacterial endotoxin on hypoxic--ischaemic injury in the immature brain of rats. Bacterial endotoxin (lipopolysaccharide 0.3 mg/kg)...
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Hypoxic-ischaemic damage to the developing brain is a leading cause of child death, with high mortality and morbidity, including cerebral palsy, epilepsy, and cognitive disabilities. The developmental stage of the brain and the severity of the insult influence the selective regional vulnerability and the subsequent clinical manifestations. The increased susceptibility to hypoxia-ischaemia (HI) ...
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ژورنال
عنوان ژورنال: The Lancet Neurology
سال: 2016
ISSN: 1474-4422
DOI: 10.1016/s1474-4422(15)00386-5